Transgenic animals in hypertension research. New approaches to old questions.
نویسندگان
چکیده
منابع مشابه
Transgenic animals in hypertension research. New approaches to old questions.
Techniques for introducing eukaryotic DNA sequences into the genomes of fertilized mammalian embryos have been available for more than 10 years. The production of transgenic animals (primarily mice) from these embryos has provided a valuable tool for the study of molecular, cellular, and whole animal physiology in the recipient. The power of the technique derives from the fact that the expressi...
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We have shown that it is possible to generate transgenic rats efficiently, allowing direct experimentation in this species, without first testing constructs in the mouse. Having developed the technology for producing transgenic rats, we now hope to generate new and precise models of hypertension and to test candidate genes that may be responsible for the phenotype in existing animal models. The...
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ژورنال
عنوان ژورنال: Hypertension
سال: 1990
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.16.3.308